Cyanobacterial peptides: Structure elucidation of natural products | |
The increasing number
of antibiotic-resistant bacteria poses a serious threat to public health. New
bioactive compounds are therefore highly desirable as new leads for drug
development. Cyanobacteria have proven to be a rich resource of new structures
of various classes, among them cyclic depsipeptides. After the identification
of a biological activity and the isolation of a new compound, its structure has
to be elucidated. Multidimensional NMR is a powerful tool for the structural
elucidation of natural products in combination with other techniques like mass
spectroscopy and chromatography. |
Publications |
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T. Neuhof; P. Schmieder; M. Seibold; K. Preussel; H. von Döhren*; "Hassallidin B - Second antifungal member of the Hassallidin family "; Bioorg Med Chem Lett. 16, 4220-4222 (2006) |
T. Neuhof; P. Schmieder; K. Preussel; R. Dieckmann; H. Pham; F. Bartl; H. von Döhren*; "Hassallidin A, a Glycosylated Lipopeptide with Antifungal Activity from the Cyanobacterium Hassallia sp."; J. Nat. Prod. 68, 695-700 (2005) |
last changes 09.03.2013, Peter Schmieder