Cyanobacterial peptides: Structure elucidation of natural products

The increasing number of antibiotic-resistant bacteria poses a serious threat to public health. New bioactive compounds are therefore highly desirable as new leads for drug development. Cyanobacteria have proven to be a rich resource of new structures of various classes, among them cyclic depsipeptides. After the identification of a biological activity and the isolation of a new compound, its structure has to be elucidated. Multidimensional NMR is a powerful tool for the structural elucidation of natural products in combination with other techniques like mass spectroscopy and chromatography.
We use modern, multidimensional NMR techniques to elucidate the structure of novel compounds from the cyanobacterium Hassallia sp., that turned out to be cyclic depsipeptides containing both a lipid chain and a carbohydrate moiety.


T. Neuhof; P. Schmieder; M. Seibold; K. Preussel; H. von Döhren*; "Hassallidin B - Second antifungal member of the Hassallidin family "; Bioorg Med Chem Lett. 16, 4220-4222 (2006)

DOI: 10.1016/j.bmcl.2006.05.094

T. Neuhof; P. Schmieder; K. Preussel; R. Dieckmann; H. Pham; F. Bartl; H. von Döhren*; "Hassallidin A, a Glycosylated Lipopeptide with Antifungal Activity from the Cyanobacterium Hassallia sp."; J. Nat. Prod. 68, 695-700 (2005)

DOI: 10.1021/np049671r

last changes 09.03.2013, Peter Schmieder